Medicines Evaluation Unit - Previous Studies - Publications

Publications

1. Singh SD, Tutuncu A, Lohr I, Carlholm M, Polanowski T. Budesonide administered using chlorofluorocarbon and hydrofluoroalkane pressurized metered-dose inhalers; pharmacokinetics, pharmacodynamics and clinical equivalence. International Journal Of Clinical Pharmacology and Therapeutics 2007;45:485-495

2. Singh SD, Richards D, Knowles RG, Schwartz S, Woodcock AA, Langley SJ, O’Connor BJ. Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma.  AJCCM 2007:18;46;22

3. Borrill ZL, Houghton CM, Tal-Singer R, Vessey SR, Faiferman I, Langley SJ, Singh  D.  The use of plethysmography and oscillometry to compare long acting bronchodilators in patients with COPD. British J Clin Pharmacol in press 2007

4. Smyth LJ, Starkey C, Vestbo J, Singh D. CD4 regulatory cells in COPD patients. Chest 2007;132:156-63

5. Houghton CM, Lawson N, Borrill ZL, Wixon C L, Yoxall SQ, Langley SJ, Woodcock AA, Singh SD. Respiratory Research 2007;8:52

6. Roy K, Borrill ZL, Starkey C, Hazel AL, Morris J, Vestbo J, Singh SD. Use of different exhaled nitric oxide multiple flow rate models in COPD. Eur Respir J 2007;29:651-659.

7. Singh SD, Tal-Singer R, Faiferman I,  Lasenby S, Henderson A, Wessels D, Goosen A, Dallow N, Vessey R, Goldman M. Plethysmography And Impulse Oscillometry Assessment Of Tiotropium And Ipratropium Bromide; A Randomised, Double Blind, Placebo Controlled, Crossover Study In Healthy Subjects. British Journal Of Clinical Pharmacology. Br J Clin Pharmacol. 2006;61:398-404

8. Borrill ZL, Clough D, Truman N, Morris J, Langley SJ, Singh SD. A comparison of exhaled nitric oxide measurements performed using 3 different analysers. Respiratory Medicine 2006;100:1392-6

9. Borrill ZL, Houghton CM, Woodcock AA, Vestbo J, Singh SD “Measuring bronchodilation in COPD clinical trials.” British Journal Of Clinical Pharmacology  2005;59:379-84

10. Borrill ZL, Starkey C, Vestbo J, Singh SD “Reproducibility Of Exhaled Breath Condensate pH In Chronic Obstructive Pulmonary Disease.” European Respiratory Journal 2005;25:269-74

11. Houghton CM, Woodcock AA, Singh SD. “A Comparison Of Plethysmography, Spirometry And Oscillometry For Assessing The Pulmonary Effects Of Inhaled Ipratropium Bromide In Healthy Subjects And Patients With Asthma.” British Journal Of Clinical Pharmacology  2005;59:152-9

12. Houghton CM, Woodcock AA, Singh SD. “A comparison of lung function methods for assessing dose-response effects of salbutamol” British Journal Of Clinical Pharmacology. 2004;58:134-41.

13. Houghton CM, Langley SJ, Singh SD, Holden J, Monici Preti AP, Acerbi D, Poli G, Woodcock A. Comparison of bronchoprotective and bronchodilator effects of a single dose of formoterol delivered by hydrofluoroalkane and chlorofluorocarbon aerosols and dry powder in a double - blind, placebo - controlled, cross-over study. Br J Clin Parmacol 2004; 58:4: 359-66

14. Kips JC, O'Connor BJ, Langley SJ, Woodcock A, Kerstjens HAM, Postma DS, Danzig M, Cuss F, Pauwels RA. The effect of SCH55700, a humanized anti-human IL-5 antibody in severe persistent asthma : a pilot study. Am J Respir Crit Care Med 2003;167:1655-1659

15. A. Woodcock, A. Williams, L. Batty, C. Masterson, A. Rossetti and L. Cantini. Effects of Lung Function, Symptoms, and Bronchial Hyperreactivity of Low-Dose Inhaled Beclomethasone Dipropionate Given with HFA-134a or CFC Propellant. Journal of Aerosol Medicine, Volume 15, Number 4, 2002. Pp. 407-414.
 

16. Stephen J Langley, Janet Holden, Alison Derham, Paul Hedgeland, Raj K Sharma, Ashley Woodcock. Fluticasone propionate via the Diskhaler® or HFA-134a MDI on Methacholine induced airway hyper-responsiveness. Chest 2002; 122: 806-811

17. Singh SD, C Whale, N Houghton, P Daley-Yates, SM Kirby, J Efthimiou, AA Woodcock. Pharmacokinetics and systemic effects of inhaled fluticasone propionate in chronic obstructive pulmonary disease and healthy volunteers: a randomised crossover study. Br J Clin Pharmacol. 2003 Apr;55(4):375-81.
 

18. Langley SJ, Sykes AP, Batty EP, Masterson CM, Woodcock A. A Comparison Of The Efficacy and Tolerability of Single Doses of HFA 134a Albuterol and CFC Albuterol in Mild to Moderate Asthmatic Patients. Ann Allergy Asthma and Immunol 2002 May;88(5):488-93

19. Brutsche MH, Carlen-Brutsche I, Munavar M, Langley SJ, Masterson CM, Daley-Yates PT, Brown R, Custovic A, Woodcock A. Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study. Lancet 2000 Aug 12;356(9229);556-61.
 

20. Langley S J, Masterson C M, Batty E P, Woodcock A. Bronchodilator Response to salbutamol after chronic dosing with salmeterol. Eur Respir J 1998, 11:1081-1085.