Medicines Evaluation Unit - Previous Studies - Publications

1.             Singh SD, Tutuncu A, Lohr I, Carlholm M, Polanowski T. Budesonide administered using chlorofluorocarbon and hydrofluoroalkane pressurized metered-dose inhalers; pharmacokinetics, pharmacodynamics and clinical equivalence. International Journal Of Clinical Pharmacology and Therapeutics 2007;45:485-495. 

2.             Singh SD, Richards D, Knowles RG, Schwartz S, Woodcock AA, Langley SJ, O’Connor BJ. Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma.  AJCCM 2007:18;46;22. 

3.             Borrill ZL, Houghton CM, Tal-Singer R, Vessey SR, Faiferman I, Langley SJ, Singh  D.  The use of plethysmography and oscillometry to compare long acting bronchodilators in patients with COPD. British J Clin Pharmacol in press 2007. 

4.             Smyth LJ, Starkey C, Vestbo J, Singh D. CD4 regulatory cells in COPD patients. Chest 2007;132:156-63. 

5.             Roy K, Borrill ZL, Starkey C, Hazel AL, Morris J, Vestbo J, Singh SD. Use of different exhaled nitric oxide multiple flow rate models in COPD. Eur Respir J 2007;29:651-659. 

6.             Singh SD, Tal-Singer R, Faiferman I,  Lasenby S, Henderson A, Wessels D, Goosen A, Dallow N, Vessey R, Goldman M. Plethysmography And Impulse Oscillometry Assessment Of Tiotropium And Ipratropium Bromide; A Randomised, Double Blind, Placebo Controlled, Crossover Study In Healthy Subjects. British Journal Of Clinical Pharmacology. Br J Clin Pharmacol. 2006;61:398-404.

7.             Houghton CM, Woodcock AA, Singh SD. “A comparison of lung function methods for assessing dose-response effects of salbutamol” British Journal Of Clinical Pharmacology. 2004;58:134-41. 

8.             Kips JC, O'Connor BJ, Langley SJ, Woodcock A, Kerstjens HAM, Postma DS, Danzig M, Cuss F, Pauwels RA. The effect of SCH55700, a humanized anti-human IL-5 antibody in severe persistent asthma : a pilot study. Am J Respir Crit Care Med 2003;167:1655-1659. 

9.             Stephen J Langley, Janet Holden, Alison Derham, Paul Hedgeland, Raj K Sharma, Ashley Woodcock. Fluticasone propionate via the Diskhaler® or HFA-134a MDI on Methacholine induced airway hyper-responsiveness. Chest 2002; 122: 806-811.

10.          Singh SD, C Whale, N Houghton, P Daley-Yates, SM Kirby, J Efthimiou, AA Woodcock. Pharmacokinetics and systemic effects of inhaled fluticasone propionate in chronic obstructive pulmonary disease and healthy volunteers: a randomised crossover study. Br J Clin Pharmacol. 2003 Apr;55(4):375-81.

11.          Brutsche MH, Carlen-Brutsche I, Munavar M, Langley SJ, Masterson CM, Daley-Yates PT, Brown R, Custovic A, Woodcock A. Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study. Lancet 2000 Aug 12;356(9229);556-61.

12.          Singh D, Kane B, Molfino NA , Cranmer H, Faggioni R, Roskos L, Woodcock A. Pharmacokinetics of an IL-13 antibody in asthma.  BMC Pulm Med  2010;10:3.

13.          Singh D, Smyth L, Borrill Z, Sweeney L, Tal-Singer R. A Randomised, Placebo Controlled Study Of The Effects Of The p38 MAPK Inhibitor SB-681323 On Blood Biomarkers Of Inflammation In COPD Patients. J Clin Pharmacol 2010;50:94-100.

14.          Kane B, Kolsum U, Southworth T, Armstrong J, Woodcock A, Singh D. The effects of smoking on the lipopolysaccharide response and glucocorticoid sensitivity of alveolar macrophages of patients with asthma. Chest. 2009;136:163-70. 

15.          Roy K, Smith J, Kolsum U, Borrill Z, Vestbo J, Singh D. COPD phenotype description using principal components analysis. Respir Res 2009; 29:10:41.

16.          Borrill Z, Roy K, Kolsum U, Southworth T, Vestbo J, Singh D. Seretide withdrawal increases airway inflamation in moderate COPD patients. Eur J Clin Pharmacol. 2009 ;65:1165-6.

17.          Kent L, Smyth L, Plumb J, Clayton C, Fox S, Ray D, Farrow S, Singh SD.  Inhibition of LPS stimulated COPD macrophage inflammatory gene expression by Dexamethasone and the p38 MAPK inhibitor SB706504. J Pharmacol Exp Ther. 2009;328:458-68.

18.          Singh SD, Fairwood J, Murdoch R, Weeks A, Russell P, Roy K, Langley S, Woodcock A. The reproducibility of adenosine monophosphate bronchial challenges in mild, steroid-naive asthmatics. Br J Clin Pharmacol. 2008;66:261-5.

19.          Singh SD, Brooks J, Hagan G, Cahn A, O'Connor B. ‘Triple’ therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD. Thorax. 2008;63:592-8.

20.          Singh SD, Piccinno A,  Borrill Z, Gianluigi Poli, Acerbi D, Meuleners L, Woodcock AA. Tolerability of high cumulative doses of the HFA modulite beclomethasone dipropionate/formoterol combination inhaler in asthmatic patients. Pulm Pharmacol Ther 2008;21:551-7.